According to IGN, Hellboy: Rise of the Blood Queen will embrace it’s “R”-rating and practical effects.
Neil Marshall (director, The Descent) had the following things to say:
“We’ve been granted permission to do it R-rated, which for me is just like taking the cuffs off, … It’s not like I’m going to force it to be R-rated, but if it happens to come out that way, just because of my own sensibilities, then fine. And nobody’s going to stop us. So, that’s the main [difference]. …but, also, when you go back the original material, it is kind of bloody, so I’m going to embrace that.”
“I love to do stuff in camera whenever I possibly can, and use CG as the amazing tool that it is, to enhance or expand upon the world, but not to use it to replace reality, when you can do it [for] real”